Subjects with constant carbohydrate and protein intake had their dietary fat content raised continuously up to a daily ingestion of more than 6,800 fat calories (yes, more than 6,000 fat calories per day). Subjects experienced only a slight weight gain, considering the significant calorie surplus.
Based on these results, obese subjects were treated with high fat, low carbohydrate diets. If the carbohydrate content of the diet was not more than 50 to 60g and the fat content approximately 150g, an average daily weight reduction of 0.3 kg was achieved. The cholesterol and triglyceride concentrations in the serum, which had been raised at the beginning of the experiment, invariably showed a tendency towards normalization under this dietary program.